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. 2020 Jun 18;48(14):8006–8021. doi: 10.1093/nar/gkaa519

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effect of PCBP-FL binding to SLIVm on SHAPE reactivity and hydroxyl-radical cleavage. (A) Schematic of SLIVm RNA topology highlighting SHAPE reactivity of the RNA. Red = Bases with the highest reactivity; Yellow = bases with high reactivity. Arrows denote increased or decreased SHAPE reactivity effected by binding of PCBP2-FL. (B) Schematic of SLIVm RNA topology highlighting effect of PCBP2-FL binding on base susceptibility to hydroxyl-radical cleavage. Dark purple = highly protected bases; Light purple = protected bases; Red = decreased protection upon PCBP2-FL binding. (C) Mapping of PCBP2-FL binding effects on SLIVm SHAPE reactivity and susceptibility to hydroxyl-radical onto derived model of the PCBP2-FL/SLIVm model.