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. 2020 Jun 29;48(14):7958–7972. doi: 10.1093/nar/gkaa532

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Structure of hADAR2-R2D E488Q bound to the GLI1 32 bp RNA at 2.8 Å resolution. (A) View of the structure perpendicular to the dsRNA helical axis. (B) View of the structure along the dsRNA helical axis. (C) Cartoon schematic of the asymmetric protein dimer. Colors for ADAR2 domains and RNA strands correspond to those used in A and B. Electron density for dsRBD2 on monomer A was not resolved. (D) Summary of contacts between hADAR2-R2D E488Q and GLI1 32 bp RNA duplex. Brown represent RNA contacts to deaminase A; blue represents RNA contacts to dsRBD2 of monomer B. Asterisk represent potential contacts that lack full side-chain electron density.