Figure 4.

ADAR contacts observed in protein dimer. (A) Protein–protein contacts within dimerization interface. Monomer A is primarily colored brown, the dimerization helix of Monomer A is colored yellow, Monomer B is colored green. (B) Contacts between dsRBD2 B and RNA duplex. dsRBD B is labeled in light blue, 8-AN containing RNA strand is labeled in light pink, the complementary strand is labeled in blue. (C) Representative sequence alignment for ADARs showing sequence conservation in dimerization helix. Conserved residues contained within ADAR2′s dimerization helix are highlighted red.