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. 2020 Jun 29;48(14):7801–7817. doi: 10.1093/nar/gkaa536

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Model for HIV-1 integration and transcription. (A) HIV-1 integration is mainly determined by LEDGF/p75 binding to H3K36me3 in active genes. HIV-1 also integrates near enhancer regions characterized by H3K27ac and H3K4me1. Integration in these areas is associated with high RNA expression. (B) LEDGIN treatment retargets integration away from actively transcribed regions to silent genes and intergenic regions, resulting in provirus with lower RNA expression. However, some LEDGF/p75-independent integrations might still occur near regulatory elements, explaining few high residual expressors even in the presence of LEDGINs.