Example traces of (A) normal breathing (eupnea), (B), apnea and (C) hypopnea. Kcna1−/− mice display (D) more apnea events and (E) fewer hypopnea events as they age. (F) Kcna1−/− mice spend significantly more time in apnea-hypopnea (A-H). Significance was determined by a two-way ANOVA for age and genotype followed by Holm-Sidak’s multiple comparisons test, n = 4-7, *
p < 0.05, **
p < 0.01.