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. Author manuscript; available in PMC: 2020 Nov 4.
Published in final edited form as: Epilepsia. 2018 Jan 12;59(2):345–357. doi: 10.1111/epi.13971

Figure 5. Seizures are triggered by lower MCh concentrations in SD90 Kcna1−/− mice.

Figure 5

(A) MCh induced seizures at lower concentrations in older Kcna1−/− mice. (B) MCh concentration response curves exhibited a leftward shift in SD90 Kcna1−/− mice for inspiratory time (Ti), (C) expiratory time (Te), and (D) and respiration rate (f). This resulted in significantly reduced MCh EC50’s (right). Significance was determined by a one-way ANOVA followed by Tukey’s multiple comparisons test, ** p < 0.01, *** p < 0.001 v. P32-36 and $$ p < 0.01, $$$ p < 0.001 v. P42-46, n = 5-6.