Table 2.
Risk factors for recurrence within 5 years (overall patients, n=1,451)
| Variable | Unadjusted |
Multivariable |
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age ≥60 vs. <60 (years) | 1.18 (1.02–1.35) | 0.025 | 1.14 (0.97–1.34) | 0.108 |
| Male vs. female | 1.21 (1.02–1.44) | 0.032 | 1.41 (1.18–1.68) | <0.001 |
| Diabetes | 1.01 (0.85–1.20) | 0.893 | ||
| HBV vs. others | 0.87 (0.74–1.02) | 0.089 | 0.98 (0.81–1.17) | 0.795 |
| ALBI grade 2 vs. 1 | 1.32 (1.16–1.52) | <0.001 | 1.23 (1.06–1.42) | 0.007 |
| FIB-4 ≥3.25 vs. <3.25 | 1.46 (1.28–1.68) | <0.001 | 1.14 (0.97–1.33) | 0.116 |
| AFP ≥10 vs. <10 (ng/mL) | 1.39 (1.21–1.60) | <0.001 | 1.49 (1.28–1.72) | <0.001 |
| Tumor number | ||||
| Single | Reference | Reference | ||
| Two | 1.44 (1.12–1.84) | 0.004 | 1.30 (1.01–1.66) | 0.041 |
| Three | 2.56 (1.45–4.54) | 0.001 | 2.17 (1.22–3.85) | 0.008 |
| Maximal tumor diameter (cm) | ||||
| ≤2 | Reference | |||
| >2 and ≤5 | 1.01 (0.88–1.17) | 0.877 | ||
| >5 | 1.13 (0.88–1.45) | 0.336 | ||
| Initial treatment modality | ||||
| Resection | Reference | Reference | ||
| RFA* | 1.78 (1.55–2.04) | <0.001 | 1.68 (1.45–1.94) | <0.001 |
HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; ALBI, albumin-bilirubin; FIB-4 score, fibrosis-4 score; AFP, alpha-fetoprotein; RFA, radiofrequency ablation.
*
Thirteen patients who received resection and radiofrequency ablation simultaneously were included in this category.