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. 2020 Oct 22;9:e58593. doi: 10.7554/eLife.58593

Figure 4. Similarity of CBD and analgesic compound binding sites.

Figure 4.

(A) Structural alignment of the NavMs-CBD complex (protein in coral ribbon depiction, CBD in green stick depiction), with the structure of the NavMs pore-PI1 complex (Bagnéris et al., 2014) [the protein is in grey ribbon depiction and the PI1 molecule is in blue stick depiction]. PI1 is a highly potent designed analgesic compound, which binds to and inhibits flux through the NavMs channel (Bagnéris et al., 2014). Two views of the aligned structural complexes, rotated by 90 degrees, are shown. They show the similarity, but not identity of the binding sites of the two ligands. (B) Detailed view showing the locations of these molecules in the pore/fenestration area. (C) Chemical structure of the PI1 compound.