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. 2020 Oct 20;11:2087. doi: 10.3389/fimmu.2020.02087

Figure 1.

Figure 1

Vaccination with FhKTM/CpG-ODN/Coa-ASC16 increases the survival rate in F. hepatica infected mice. (A) Scheme of the vaccination and challenge experiments. BALB/c mice were injected s.c. in the upper and dorsal region on days 0, 7, and 14 with FhKTM/CpG-ODN/Coa-ASC16, CpG-ODN/Coa-ASC16, or PBS (infected). One week later, the mice were oral-challenged with 6 metacercariae of F. hepatica. Non-vaccinated non-infected (untreated) mice were used as a negative control group. The samples were obtained at 4 and 24 dpi. (B) Survival was monitored for >75 days. Each group comprised of five mice. Survival was significantly higher in the FhKTM/CpG-ODN/Coa-ASC16-immunized mice than in the control groups. Kaplan–Meier curves were generated and survival was compared across groups using the log-rank test **p < 0.05. This figure is representative of two experiments with similar results.