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. 2020 Oct 20;11:586806. doi: 10.3389/fphar.2020.586806

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Copyright © 2020 Wei, Ma, Niu, Wang, Yang, Wang, Wen, Li and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The pivotal “specific metabolite-target-component” interactive network of PF in the treatment of cholestatic liver injury. The yellow triangles represent PF. The blue dots represent the protein targets of PF. The green squares represent the protein targets of specific metabolites. The yellow dots represent specific metabolites. (B) Changes in the metabolic level of the specific metabolites directly and indirectly regulated by PF. ^∗ p < 0.01 compared with the normal group; ^## p < 0.01, ^# p < 0.05 compared with the BDL group.