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Acacetin inhibits MMP expression in vivo. (a) Immunohistochemical analysis of cartilage samples from knee joints for MMP-1, MMP-3, and MMP-13 at 6 weeks after ACLT surgery in mice in the sham, OA, H-acacetin, and L-acacetin groups (n = 6 per group). (b) Percentages of immune-positive cells in each group. n = 6, ∗P < 0.05, and ∗∗P < 0.01. Scale bar = 50 μm.
