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Risk of bias assessment: notes: Domain 1: random number generation; Domain 2: allocation concealment; Domain 3: blinding of patients and clinicians; Domain 4: blinding of outcome evaluators; Domain 5: completeness of outcome data; Domain 6: selective reporting; Domain 7: other sources of bias; “++”: definitely low risk of bias; “+”: probably low risk of bias; “−“: probably high risk of bias; H: overall high risk of bias; and M: overall moderate risk of bias.
