Table 2.
Predictive factors for RP-ILD in DM patients using univariate and age- and gender-adjusted multivariate logistic regression analyses.
| Predictor | Univariate analysis | Age- and gender-adjusted multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p value | Odds ratio | 95% CI | p value | |
| Age (yrs) | 1.005 | 0.974-1.036 | 0.767 | |||
| Gender (female) | 1.279 | 0.501-3.264 | 0.607 | |||
| Anti-MDA-5-positive | 3.584 | 1.530-8.393 | 0.003 | 3.910 | 1.629-9.382 | 0.002 |
| Anti-ARS-positive | 2.025 | 0.813-5.042 | 0.130 | 1.988 | 0.795-4.974 | 0.142 |
| sCD206 (ng/ml) | 1.004 | 1.003-1.006 | <0.0001 | 1.005 | 1.003-1.007 | <0.0001 |
| CRP (mg/dl)a | 1.054 | 0.981-1.131 | 0.149 | 1.052 | 0.979-1.131 | 0.166 |
| ESR (mm/H)b | 1.019 | 1.003-1.035 | 0.017 | 1.020 | 1.004-1.036 | 0.015 |
| Ferritin (ng/ml)c | 1.002 | 1.001-1.003 | 0.002 | 1.002 | 1.001-1.004 | 0.002 |
| %FVC (%)d | 0.929 | 0.893-0.966 | <0.0001 | 0.928 | 0.892-0.964 | <0.0001 |
| CK (IU/l) | 1.000 | 1.000-1.000 | 0.989 | 1.000 | 1.000-1.000 | 0.964 |
| Muscle weakness | 0.542 | 0.237-1.240 | 0.147 | 0.541 | 0.235-1.245 | 0.149 |
| Heliotrope sign | 0.748 | 0.331-1.688 | 0.485 | 0.752 | 0.333-1.699 | 0.493 |
| Gottron papules | 1.732 | 0.729-4.113 | 0.213 | 1.734 | 0.729-4.123 | 0.213 |
| Mechanic's hands | 2.633 | 1.151-6.023 | 0.022 | 2.593 | 1.125-5.976 | 0.025 |
| Skin ulcer | 1.432 | 0.544-3.769 | 0.467 | 1.517 | 0.567-4.059 | 0.406 |
| Arthritis/arthralgia | 1.150 | 0.488-2.707 | 0.750 | 1.143 | 0.485-2.695 | 0.760 |
| Dysphagia | 0.641 | 0.240-1.709 | 0.374 | 0.613 | 0.224-1.675 | 0.340 |
| Elevated sCD206 (≥792.75 ng/ml) | 11.222 | 4.466-28.200 | <0.0001 | 12.679 | 4.844-33.182 | <0.0001 |
| Elevated ferritin (≥417.7 ng/ml)c | 7.837 | 2.690-22.830 | <0.0001 | 11.416 | 3.383-38.525 | <0.0001 |
DM: dermatomyositis; RP-ILD: rapidly progressive interstitial lung disease; sCD206: soluble CD206; ARS: aminoacyl-tRNA synthetases; MDA-5: melanoma differentiation-associated gene-5; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; CK: creatine kinase; %FVC: percent predicted forced vital capacity. a,b,c,dData were available for 140, 142, 85, and 94 patients, respectively.