Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 25;48(19):11172–11184. doi: 10.1093/nar/gkaa772

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — Model of CCAN – Cenp-A^Nuc with fitted Cenp-HIK^Head-TW. (A) Two orthogonal views of the CCAN – Cenp-A^Nuc complex with the fitted Cenp-HIK^Head-TW sub-module. (B) Two close-up views of the fitted Cenp-HIK^Head-TW sub-module showing basic residues of Cenp-I^Head and Cenp-T that interact with the DNA gyre of Cenp-A^Nuc. Of the residues indicated, Cenp-I^K216, Cenp-T^K279, Cenp-T^K295, Cenp-W^R71 are conserved in H. sapiens. (C) Regions of CCAN that contact the Cenp-A^Nuc DNA duplex feature positive electrostatic surfaces. The left panel shows the positively charged surface on Cenp-HIK^Head-TW that contacts the DNA gyre close to SHL3. Right panel shows the positively charged DNA-binding groove of the Cenp-LN channel that engages the unwrapped DNA duplex at the terminus of Cenp-A^Nuc.