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. 2020 Sep 25;48(19):11172–11184. doi: 10.1093/nar/gkaa772

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model for the (CCAN)₂ – Cenp-A^Nuc complex. (A) Two orthogonal views of the complex showing how Cenp-A^Nuc slots into the groove formed by the association of two ‘Y’-shaped CCAN protomers. The unwrapped DNA at the two Cenp-A^Nuc termini engage the DNA-binding groove of Cenp-LN at the centre of each CCAN protomer. (B) Close-up view of the interaction between Cenp-HIK^Head-TW and Cenp-OPQU+ of the symmetry-related protomer with Cenp-OPQU+ shown in surface representation. There is a slight clash of Cenp-TW with Cenp-OPQU+.