Table 1.

Bulge-inducing conjugates: nomenclature, sequence, peptide and association constants (Ka)

Conjugate	Oligonucleotide (5′→3′)	Peptide	Ka × 106 M−1
BC2	TGGTGCGAATT-A*-GTGGATCGAA	[LR]4G	0.9 ± 0.3
BC3	TGGTGCGAATT-A*-TGGATCGAA	[LR]4G	0.5 ± 0.1
BC4	TGGTGCGAATT-A*-GGATCGAA	[LR]4G	0.4 ± 0.2
BC5	TGGTGCGAATT-A*-GATCGAA	[LR]4G	0.0042 ± 0.002
BC2-α/BC2-β	TGGTGCGAATT-dR-GTGGATCGAACACAG	[LRLRG]2	0.9 ± 0.6/0.8 ± 0.3
BC3-α/BC3-β	TGGTGCGAATT-dR-TGGATCGAACACAG	[LRLRG]2	0.7 ± 0.6/1.0 ± 0.5
BC4-α/BC4-β	TGGTGCGAATT-dR-GGATCGAACACAG	[LRLRG]2	1.0 ± 0.8/0.9 ± 0.6
BC5-α/BC5-β	TGGTGCGAATT-dR-GATCGAACACAG	[LRLRG]2	0.4 ± 0.2/0.5 ± 0.2
BC5L-α/BC5L-β	TGGTGCGAATT-dR-GATCGAACACAGGAC	[LRLRG]2	0.9 ± 0.6/0.5 ± 0.2