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. 2020 Oct 13;48(19):10867–10876. doi: 10.1093/nar/gkaa817

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Schematic representation of MYC and its flanking enhancers. The MYC locus is at or close to an inter-TAD boundary with the flanking TADs marked in the background as blue or red spheres. From its default state it will upon transcriptional activation connect with the enhancer regions in both of its flanks switching between the TADs in a mutually exclusive manner. It is also envisaged that these processes are controlled by external factors produced in the microenvironment of the evolving cancer cells.