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. 2020 Oct 12;48(19):10909–10923. doi: 10.1093/nar/gkaa858

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Senescence-activated enhancers (SAEs) affect adjacent SASP gene expression profiles. (A, B) Gene Ontology enrichments of SAEs (A) and SIAEs (B) by GREAT. The length of each bar represents the enriched P value for each biological process. (C) Heatmaps displaying normalized gene expression among PD2, PD8, and PD14. SAE- (left panel) and SIAE- (right panel) adjacent genes are listed. (D, E) H3K27ac ChIP-Seq occupancy profiles at representative SAE and SIAE loci for the Cxcl and Hoxc families. The genes in these two families that are adjacent to SAEs and SIAEs are marked by blue boxes.