Table 4.

Function of the enzymes used in the base excision repair enzyme mixture for initiating in vitro repair of the PhenDC3-induced DNA damage

Repair Enzyme	Function of repair enzyme
Formamidopyrimidine DNA glycosylase	Recognizes and removes 8-oxo-7,8- dihydroguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine
Endonuclease III	Recognizes and removes various pyrimidine lesions, that includes 5,6-dihydroxythymine, uracil glycol, 5-hydroxy-6-hydrothymine
Endonuclease IV	Recognizes and acts on abasic sites, 3′-phosphate, 3′-phosphoglycolate
Endonuclease VIII	Recognizes and removes various pyrimidine lesions that includes urea, uracil glycol, 5,6-dihydroxythymine
Apurinic/apyrimidinic endonuclease 1	Recognizes and acts on abasic sites, 3-phosphate, 3′-phosphoglycolate