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. 2020 Nov 4;20:1063. doi: 10.1186/s12885-020-07500-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — a-b Treatment of 4 T1 TNBC xenograft model with vehicle control, RX-5902 (60 mg/kg), anti-mouse PD-1 (100 μg/mouse) or the combination. TGI compared to vehicle: RX-5902 60 (TGI = 44%; p = 0.007), anti-mouse-PD-1 (TGI = 21%; p = 0.173), combination (TGI = 61%; p = 0.001). Combination compared to RX-5902 alone and anti-mouse-PD-1 alone (p = 0.032 and p = 0.001, respectively). c-d Treatment of 4 T1 TNBC xenograft model with vehicle control, RX-5902 (35 mg/kg), RX-5902 (75 mg/kg), RX-5902 (35 mg/kg) plus anti-CTLA-4 (5 mg/kg) or RX-5902 (75 mg/kg) plus anti-CTLA-4 (5 mg/kg) resulted in TGI at day 25 compared to vehicle control: TGI 35%, p = 0.006; TGI 76%, p < 0.001; TGI 67%, p < 0.001, TGI 76%, p < 0.001. Combination of RX-5902 (35 mg/kg) plus anti-CTLA-4 (5 mg/kg) compared to RX-5902 alone (p = 0.007). * p < 0.05, **p < 0.01