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. 2020 Nov 4;20:1063. doi: 10.1186/s12885-020-07500-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Human immune subsets in spleens and tumors of hu-CB-BRGS MDA-MB-231 bearing mice at the end of study. a Flow cytometry panel for identification of mouse (mCD45) and human (mCD45) hematopoietic cells, and T (CD3) and B (CD20) cells among the hCD45+ population (right), in the spleen (top) and tumor (bottom). b Percentage of human (hCD45+ of (mCD45⁺ + hCD45⁺)) cells in the spleens and tumors. c T cell (CD3+) numbers and frequencies and d among the hCD45+ cells. e Representative fields from tumors collected at end of study from the indicated treatment arms stained with anti-CD3 antibodies (green) and DAPI and imaged using the Vectra 3.0 system. f Frequency of live cells among CD8+ human (hCD45+) cells in tumors. Each dot represents data from an individual spleen, bone marrow or tumor from mice receiving either no drug (Vehicle), nivolumab alone (Nivo), RX-5902 alone, or combination of nivolumab and RX-5902 (Combo) treatment. Lines represent arithmetic means. p-value: * < 0.05