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. 2020 Nov 4;12:167. doi: 10.1186/s13148-020-00960-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — STRING diagrams showing functional relationships between hyper- and hypo-methylated DMFs within gene regions (a) and functional relationships between hyper- and hypo-methylated DMCs within gene regions (b). Colours highlighting specific genes indicate their presence within an overrepresented functional pathway determined through a STRING analysis. Functional pathways all have a FDR-corrected P value < 0.05. A full list of the functional pathways with associated P values and gene numbers in sets is included in Additional file 1: Excel file ‘DMAP_Pathways and ‘MethylKit_Pathways’