Table 2.
Genes linked to regulatory features overlapping with clusters of differential methylation
| Gene ID | Regulatory element | Cluster | Description |
|---|---|---|---|
| XAF1 | GH17J005769 | CHR17 | A negative regulator of the inhibitor of apoptosis (IAP) family resulting in increased stress induced apoptosis |
| ZNF594 | GH17J005769 | CHR17 | Implicated in transcriptional regulation |
| DUSP22 | GH06J000290 + Region of enhancer (GH06J000290) and gene interaction | CHR6 | Activator of the JnK pathway involved in apoptosis, inflammation, cytokine production and metabolism |
| EXOC2 | GH06J000290 | CHR6 | A component of the exocyst complex important for the targeting of vesicles to docking sites on the plasma membrane |
| IRF4 | GH06J000290 + Region of enhancer (GH06J000225) and gene interaction | CHR6 | A lymphocyte specific member of the interferon regulatory factor family of transcription factors for regulation of interferons in response to infection by virus |
| UCP2 | Region of enhancer (GH11J073778) and gene interaction | CHR11 | A member of the mitochondrial uncoupling protein family that creates proton leaks across the inner mitochondrial membrane |
| DNAJB13 | Region of enhancer (GH11J073968) and gene interaction | CHR11 | A heat shock protein with an important role in the formation of the central complex of ciliary and flagellar axonemes |
| DUS3L | Gene Body Overlap + GH19J005798 + Region of enhancer (GH19J006270) and gene interaction | CHR19 | A protein catalyzing the synthesis of dihydrouridine |
| LONP1 | GH19J005798 | CHR19 | A mitochondrial matrix protein that mediates the selective degradation of damage and the regulation of mitochondrial gene expression |
| CATSPERD | GH19J005798 | CHR19 | A component of the CatSper complex involved in sperm cell hyperactivation |
| FUT6 | GH19J005798 | CHR19 | A Golgi stack membrane protein involved in the creation of the blood group antigen sialyl-Lewis X |
| FUT3 | GH19J005798 | CHR19 | An enzyme that catalyzes the final step of Lewis antigen biosynthesis involved in the expression of; Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewix X/SSEA-1 antigens |
| FUT5 | GH19J005798 | CHR19 | A paralog of FUT6 |
| NDUFA11 | GH19J005798 | CHR19 | A subunit of the membrane bound mitochondrial complex I which functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain |
| VMAC | GH19J005798 + Region of enhancer (GH19J005620) and gene interaction | CHR19 | A vimentin-type intermediate filament-associated coiled-coil protein |
| NRTN | GH19J005798 + Region of enhancer (GH19J005798) and gene interaction | CHR19 | A member of the GDNF family for survival and function of neurons. Implicated in immune responses with PBMCs—up-regulation indicating immune cells are communicating via NRTN |
| SAFB | Region of enhancer (GH19J006055) and gene interaction | CHR19 | Implicated with stress responses, cell cycle, apoptosis and cell differentiation |
Annotation includes the ‘GeneHancer’ ID of the associated differentially methylated enhancer, or the enhancer identified in the four clusters of differentially methylated region of regulatory interaction. Also included is the chromosome in which the cluster was located along with a brief description of the gene function. All are associated with hypo-methylated clusters except the rows highlighted italic that indicate association with a hyper-methylated cluster