Table 1.
Demographics and outcomes of the ICU population and a comparison between the sepsis and non-sepsis cohorts
| ICU population | Sepsis cohort | Non-sepsis cohort | p value | |
|---|---|---|---|---|
| Number, n (% of ICU population) | 1867 (100) | 632 (33.9) | 1235 (66.1) | |
| Age in years, median (IQR) | 67 (54–75) | 69 (61–76) | 65 (49.5–73) | < 0.001 |
| Female sex, n (%) | 738 (39.5) | 251 (39.7) | 487 (39.4) | 0.95 |
| Department of origin | ||||
| Emergency department/out of hospital, n (%) | 896 (48) | 276 (43.7) | 620 (50.2) | 0.008 |
| Hospital ward, n (%) | 604 (32.4) | 282 (44.6) | 322 (26.1) | < 0.001 |
| Intermediate, n (%) | 50 (2.7) | 32 (5.1) | 18 (1.5) | < 0.001 |
| Operating room/postoperative ward, n (%) | 317 (17) | 42 (6.6) | 275 (22.3) | < 0.001 |
| Organ dysfunction and illness severity on ICU admission | ||||
| SAPS3 score, median (IQR) | 59 (47–71) | 66 (57–77) | 54 (43–67) | < 0.001 |
| SAPS3 EMR30-day, median (IQR) | 17.6 (5.2–40.3) | 29.9 (14.8–53) | 11.1 (3.1–31.9) | < 0.001 |
| SOFA score, median (IQR) | 6 (3–9) | 7 (5–10) | 4 (1–8) | < 0.001 |
| Cardiovascular SOFA score (n = 1836), median (IQR) | 1 (0–3) | 3 (0–4) | 1 (0–3) | < 0.001 |
| Outcomes | ||||
| ICU mortality, n (%) | 208 (11.1) | 86 (13.6) | 122 (9.9) | 0.019 |
| 30-day mortality, n (%) | 402 (21.5) | 174 (27.5) | 228 (18.5) | < 0.001 |
| 1-year mortality, n (%) | 622 (33.3) | 261 (41.3) | 361 (29.2) | < 0.001 |
| ICU length of stay in days, median (IQR) | 1.6 (0.8–3.6) | 2.5 (1.1–5.5) | 1.1 (0.7–2.7) | < 0.001 |
| CRRT use during ICU stay, n (%) | 169 (9) | 96 (15.2) | 73 (5.9) | < 0.001 |
| bio-ADM | ||||
| bio-ADM pg/mL, median (IQR) | 40 (21–86) | 74 (42–145) | 29 (18–56) | < 0.001 |
| bio-ADM> 70 pg/mL, n (%) | 564 (30.2) | 333 (52.7) | 231 (18.7) | < 0.001 |
Data regarding general characteristics, outcomes, organ dysfunction and illness severity are presented. The sepsis cohort was compared to the non-sepsis cohort, and the p values refer to that comparison. Proportions (%) are within their subgroups unless otherwise specified. ICU: intensive care unit; IQR: interquartile range; SAPS3: Simplified Acute Physiology Score III; EMR30-day: estimated 30-day mortality risk; SOFA: Sequential Organ Failure Assessment; CRRT: continuous renal replacement therapy; bio-ADM: circulating bioactive adrenomedullin