Table 3.

Odds ratios for bio-ADM from multivariable binary logistic regression analyses for different outcomes

Outcome	ICU population			Sepsis cohort
	OR	95% CI	p value	OR	95% CI	p value
30-day mortality	1.22	1.12–1.32	< 0.001	1.23	1.07–1.41	0.003
30-day mortality†	N/A	N/A	N/A	1.20	1.04–1.38	0.010
Cardiovascular SOFA$\ge$ 3	1.33	1.23–1.42	< 0.001	1.33	1.17–1.50	< 0.001
CRRT use during ICU stay	2.28	2.01–2.59	< 0.001	1.97	1.64–2.36	< 0.001
Sepsis	1.91‡	1.76–2.08‡	< 0.001‡‡	N/A	N/A	N/A
Sepsis*	1.78‡	1.64–1.94‡	< 0.001‡	N/A	N/A	N/A
Septic shock	1.95	1.76–2.16	< 0.001	1.45	1.28–1.65	< 0.001
Septic shock*	1.78‡	1.60–1.98‡	< 0.001‡	1.35	1.19–1.54	< 0.001

The odds ratio for bio-ADM was calculated on a base 2 logarithmic scale. Age was included as a covariate in all regressions not including simplified acute physiology score III (SAPS3), as this is already an integral part of SAPS3. An additional covariate for the ^† model was lactate, and for the * models, the SAPS3 was included. If the Hosmer–Lemeshow test was $p<$ 0.05, the model was marked ^‡. ICU: intensive care unit; OR: odds ratio; CI: confidence interval; SOFA: Sequential Organ Failure Assessment; CRRT: continuous renal replacement therapy; N/A: not applicable