Fig. 4.

Effect of ALDO+RA treatment on cellular metabolism. a The fold change in expression on ALDO+RA treatment in MR-inducible MCF-7 cells for differentially expressed metabolic genes. b Schematic diagram of the glycolysis pathways (adapted from [31]), highlighting in red the key genes that show differential expression in the ALDO+RA treatment. c Heatmap of the expression level of key genes involved in glucose metabolism in normal samples, cancer samples, cancer samples expressing high level of both MR and RARB and cancer samples expressing low level of both MR and RARB from the TCGA breast cancer RNA-Seq dataset