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. 2020 Nov 3;20:534. doi: 10.1186/s12935-020-01623-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Overexpression of miR-206 increased the resistance of EOC to cisplatin. A2780s and OV2008 cells were stably transfected with pre-miR-206 or vector control and then subjected to different assays. a qRT-PCR showed miR-206 expression in parental cisplatin-sensitive EOC cell lines A2780s and OV2008 and their cisplatin-resistant variants A2780CP and C13. b qRT-PCR showed miR-206 expression in various EOC cell lines. c The MTS results show the dose–response curve of cisplatin. d The IC50 values are shown. e Flow cytometry results showed the comparison of the cell populations in the G0/G1, S and G2/M phases between the A2780s and A2780s-206 groups. f Bar graphs showing the percentage of cells in the G2 phase detected by flow cytometry. g Annexin V flow cytometry assessment of the apoptotic cell population after 24 h of cisplatin treatment. h The percentage of cells in early apoptosis