Table 7.
Treatment-specific prediction of the presence of nADA in the replication data
| Preparation | Model | Cohort | OR | 95% CI | p | AUC | R2 | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|---|
| IFNβ-1a s.c. | Without genetics | KI | 0.65 | 0.08 | 0.66 | 0.52 | |||
| IFNβ-1a s.c. | Without genetics | TUM | 0.60 | 0.06 | 0.71 | 0.42 | |||
| IFNβ-1a s.c. | PRS nADA presence 5 × 10−08 | KI | 3.89 | 2.35–6.45 | 1.44 × 10−07 | 0.85 | 0.42 | 0.78 | 0.78 |
| IFNβ-1a s.c. | PRS nADA presence 5 × 10−08 | TUM | 2.56 | 1.56–4.21 | 2.11 × 10−04 | 0.76 | 0.24 | 0.68 | 0.65 |
| IFNβ-1a s.c. | PRS top 30% vs. bottom 30% | KI | 73.86 | 11.77–463.61 | 4.42 × 10−06 | 0.91 | 0.59 | 0.78 | 0.90 |
| IFNβ-1a s.c. | PRS top 30% vs. bottom 30% | TUM | 13.78 | 3.00–63.28 | 7.45 × 10−04 | 0.83 | 0.38 | 0.80 | 0.76 |
| IFNβ-1a s.c. | SNP rs77278603 additive coding | KI | 4.49 | 2.41–8.36 | 2.14 × 10−06 | 0.82 | 0.36 | 0.74 | 0.74 |
| IFNβ-1a s.c. | SNP rs77278603 additive coding | TUM | 3.88 | 1.78–8.47 | 6.67 × 10−04 | 0.73 | 0.21 | 0.63 | 0.74 |
| IFNβ-1a s.c. | SNP rs77278603-A dominant coding | KI | 9.16 | 2.48–33.79 | 8.79 × 10−04 | 0.78 | 0.31 | 0.57 | 0.76 |
| IFNβ-1a s.c. | SNP rs77278603-A dominant coding | TUM | 3.85 | 1.10–13.49 | 3.51 × 10−02 | 0.72 | 0.20 | 0.56 | 0.68 |
| IFNβ-1b s.c. | Without genetics | KI | 0.70 | 0.15 | 0.48 | 0.82 | |||
| IFNβ-1b s.c. | Without genetics | TUM | 0.58 | 0.02 | 0.82 | 0.20 | |||
| IFNβ-1b s.c. | PRS nADA presence 1 × 10−06 | KI | 2.40 | 1.45–3.97 | 6.46 × 10−04 | 0.78 | 0.33 | 0.57 | 0.85 |
| IFNβ-1b s.c. | PRS nADA presence 1 × 10−06 | TUM | 2.15 | 1.43–3.23 | 2.28 × 10−04 | 0.73 | 0.22 | 0.73 | 0.58 |
| IFNβ-1b s.c. | PRS top 30% vs. bottom 30% | KI | 10.16 | 2.30–44.95 | 2.25 × 10−03 | 0.83 | 0.46 | 0.58 | 0.87 |
| IFNβ-1b s.c. | PRS top 30% vs. bottom 30% | TUM | 5.97 | 2.03–17.52 | 1.14 × 10−03 | 0.78 | 0.33 | 0.69 | 0.75 |
| IFNβ-1b s.c. | SNP rs28366299 additive coding | KI | 4.51 | 1.72–11.80 | 2.14 × 10−03 | 0.77 | 0.31 | 0.57 | 0.82 |
| IFNβ-1b s.c. | SNP rs28366299 additive coding | TUM | 6.91 | 3.18–15.03 | 1.07 × 10−06 | 0.79 | 0.32 | 0.74 | 0.61 |
| IFNβ-1b s.c. | SNP rs28366299-A dominant coding | KI | 9.78 | 2.68–35.74 | 5.62 × 10−04 | 0.83 | 0.40 | 0.62 | 0.83 |
| IFNβ-1b s.c. | SNP rs28366299-A dominant coding | TUM | 7.56 | 3.01–19.02 | 1.71 × 10−05 | 0.80 | 0.33 | 0.77 | 0.57 |
Predictors in the model without genetics: sex, age, treatment duration, and titration site. The genetic models contained the same base model plus the indicated genetic factors and ancestry components. The top models are indicated in bold font. OR odds ratio; CI 95% confidence interval; p p value of the genetic component; AUC area under the receiver operating characteristic curve; R2 Nagelkerke's pseudo-R2; KI Karolinska Institutet, Sweden; TUM Technical University of Munich, Germany