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. 2020 Nov 4;11:466. doi: 10.1186/s13287-020-01972-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Metabolomics analysis of ovarian tissues from the control and POI groups. a Heat map analysis of differential metabolites changes induced by chemotherapy in ovarian samples (control and POI groups). b OPLS-DA score plot of ovarian samples from both the control and POI groups. c Z-score plot of the screened metabolites in the ovarian samples of the control group and POI group. Each spot represents a metabolite. The control group is shown in blue, and the POI group is shown in red. Z-scores are sorted in descending order, in which the magnitude of the change indicates the fold by which the mean of the control group is higher or lower than its standard deviation. d Volcano plot of screened differential metabolites for both groups. Each spot represents a metabolite, and the scattered spots represent the final screening results. Significantly upregulated metabolites are shown in red, significantly downregulated metabolites are shown in blue, and nonsignificantly different metabolites are shown in black. e KEGG was used to analyze the metabolic pathways in ovarian tissues, and metabolic pathways with P < 0.05 are shown