Table 1.
Demographics, clinical features, and treatment characteristics of patients with Crimean–Congo haemorrhagic fever by use of ROTEM analysis
| All cases (n=65) | Mild cases (n=49) | Moderate to severe cases (n=16) | p value | ||
|---|---|---|---|---|---|
| Sex | |||||
| Male | 40 (62%) | 31 (63%) | 9 (56%) | .. | |
| Female | 25 (38%) | 18 (37%) | 7 (44%) | 0·77 | |
| Mean age, years | 53 (15·6) | 53·9 (16·6) | 50·3 (11·8) | 0·43 | |
| Tick bite | |||||
| Yes | 45 (69%) | 36 (73%) | 9 (56%) | .. | |
| No | 20 (31%) | 13 (27%) | 7 (44%) | 0·22 | |
| Mode of admission | |||||
| Direct | 56 (86%) | 44 (90%) | 12 (75%) | .. | |
| Hospital transfer | 9 (14%) | 5 (10%) | 4 (25%) | 0·21 | |
| Median time from symptom onset to admission, days | 2 (0–7; 2–4) | 3 (1–8; 2–4) | 4 (1–8; 3–6) | 0·07 | |
| Median length of admission, days | 8 (2–16; 6–10) | 8 (3–16; 7–10) | 8 (2–11; 6–9) | 0·45 | |
| Fatal outcome | |||||
| Yes | 2 (3%) | 0 (0%) | 2 (12%) | .. | |
| No | 63 (97%) | 49 (100%) | 14 (88%) | 0·06 | |
| Haemorrhage during admission | |||||
| Yes | 13 (20%) | 7 (14%) | 6 (37%) | .. | |
| No | 52 (80%) | 42 (86%) | 10 (63%) | 0·07 | |
| Blood product replacement | |||||
| Platelets | 21 (32%) | 13 (27%) | 9 (56%) | 0·03 | |
| Fresh frozen plasma | 15 (23%) | 7 (14%) | 9 (56%) | 0·002 | |
| Red blood cells | 8 (12%) | 3 (6%) | 5 (31%) | 0·02 | |
| Ribavirin treatment | |||||
| Yes | 35 (54%) | 23 (47%) | 12 (75%) | .. | |
| No | 30 (46%) | 26 (53%) | 4 (25%) | 0·08 | |
Data are n (%), mean (SD), or median (range; IQR). ROTEM=rotational thromboelastometry.