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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Curr Opin Genet Dev. 2020 Jun 20;64:1–5. doi: 10.1016/j.gde.2020.05.035

Figure 1: In vitro cell fates for hematopoietic stem cells.

Figure 1:

Hematopoietic stem cells (HSCs) can be either maintained in quiescence, or stimulated into cell cycle where symmetric self-renewal, asymmetric self-renewal, or symmetric differentiation is possible. HSCs differentiate into hematopoietic progenitor cells (HPCs). Alternatively, HSCs may undergo cell death or senescence. Recent improvements in the in vitro expansion of HSCs have been made through identifying and modulating both agonists and antagonists of HSC self-renewal.