Table 3.
Association with covariates and MI or stroke in multivariate analyses (n=8,214)
| Covariate | MI | Stroke | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Lp(a) (per SD increase) | 1.43 (1.16, 1.77) | .001 | 1.14 (0.90, 1.44) | .29 |
| Demographics | - | - | - | - |
| Age (per year) | 1.07 (1.06, 1.09) | <.001 | 1.05 (1.04, 1.07) | <.001 |
| Female | 0.40 (0.27, 0.58) | <.001 | 0.73 (0.49, 1.10) | .13 |
| Race/ethnicity | - | .10 | - | .13 |
| Non-Hispanic white | Reference | - | Reference | - |
| Non-Hispanic black | 0.66 (0.40, 1.09) | - | 0.93 (0.56, 1.55) | - |
| Mexican American | 0.65 (0.42, 1.03) | - | 0.61 (0.37, 1.01) | - |
| Other | 1.29 (0.43, 3.91) | - | 1.80 (0.76, 4.23) | - |
| Marital status | - | - | - | - |
| Divorced/ separated | - | - | - | - |
| Widowed | - | - | - | - |
| Never married | - | - | - | - |
| Married/living with partner | - | - | - | - |
| Education (per additional year) | - | - | - | - |
| Income <$20,000 | 1.62 (1.09, 2.39) | .02 | 2.11 (1.33, 3.45) | .001 |
| Clinical risk factors and biomarkers | - | - | - | - |
| Ever smoker | 2.47 (1.71, 3.58) | <.001 | - | - |
| Diabetes | 1.99 (1.25, 3.17) | .004 | 3.35 (2.09, 5.37) | <.001 |
| Hypertension | 1.95 (1.35 (2.83) | <.001 | 1.89 (1.24, 2.86) | .003 |
| Relative with MI before age 50 | 2.43 (1.49, 3.95) | <.001 | - | - |
| Non-HDL-C (per SD increase) | 1.43 (1.22, 1.68) | <.001 | 1.21 (1.00, 1.47) | .051 |
| C-reactive protein (per 1 mg/dL) eGFR (mL/min/ 1.73 m2) | 1.31 (1.16, 1.48) | <.001 | 1.22 (1.07, 1.40) | .004 |
HDL, high-density lipoprotein; Lp(a), lipoprotein(a); MI, myocardial infarction.