Supplement Table 2.
Association of covariates with MI and stroke in univariate analyses
| Covariate | MI | Stroke | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Lp(a) (per SD increase) | 1.36 (1.14, 1.62) | .001 | 1.19 (0.98, 1.45) | .09 |
| Demographics | - | - | - | - |
| Age (per year) | 1.07 (1.06, 1.08) | <.001 | 1.07 (1.06, 1.08) | <.001 |
| Female | 0.50 (0.37, 0.69) | <.001 | 1.07 (0.74, 1.56) | .72 |
| Race/ethnicity | - | <.001 | - | <.001 |
| Non-Hispanic white | Reference | - | Reference | <.001 |
| Non-Hispanic black | 0.73 (0.54, 0.99) | - | 1.21 (0.87, 1.69) | - |
| Mexican American | 0.36 (0.25, 0.52) | - | 0.45 (0.30, 0.67) | - |
| Other | 0.80 (0.35, 1.83) | - | 1.15 (0.50, 2.61) | - |
| Marital status | - | <.001 | - | <.001 |
| Never married | Reference | - | Reference | - |
| Divorced/separated | 5.37 (2.22, 13.00) | - | 5.57 (2.14, 14.53) | - |
| Widowed | 14.15 (6.16, 32.48) | - | 18.3 (7.71, 43.38) | - |
| Married/living with partner | 4.79 (2.13, 10.76) | - | 3.22 (1.36, 7.61) | - |
| Education (per additional year) | 0.88 (0.85, 0.91) | <.001 | 0.85 (0.82, 0.88) | <.001 |
| Income <$20,000 | 2.22 (1.61, 3.07) | <.001 | 3.13 (2.10, 4.69) | <.001 |
| Clinical risk factors and biomarkers | - | - | - | - |
| Ever smoker | 3.05 (2.21, 4.20) | <.001 | 1.62 (1.13, 2.33) | .01 |
| Diabetes | 4.66 (3.14, 6.91) | <.001 | 7.08 (4.66, 10.75) | <.001 |
| Hypertension | 4.54 (3.27, 6.30) | <.001 | 4.69 (3.17, 6.93) | <.001 |
| Relative with MI before age 50 | 1.58 (1.04, 2.39) | .03 | 1.12 (0.69, 1.81) | .64 |
| Non-HDL-C (per SD increase) | 1.69 (1.51, 1.91) | <.001 | 1.59 (1.37, 1.86) | <.001 |
| C-reactive protein (per 1 mg/dL) | 1.53 (1.35, 1.73) | <.001 | 1.56 (1.34, 1.82) | <.001 |
| eGFR (mL/min/1.73 m2) | 0.94 (0.93, 0.95) | <.001 | 0.95 (0.93, 0.96) | <.001 |
eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; Lp(a), lipoprotein(a); MI, myocardial infarction.