Supplement Table 3.
Association of covariates with MI and stroke in multivariate analyses with polynomials and interactions included, shown as average marginal effects
| Covariate | MI | Stroke | ||
|---|---|---|---|---|
| dy/dx (standard error) | P-value | dy/dx (standard error) | P-value | |
| Lp(a) (per SD increase) | 0.0092 (0.0030) | .002 | 0.0025 (0.0022) | .26 |
| Demographics | - | - | - | - |
| Age (per year) | 0.0014 (0.0002) | <.001 | 0.0009 (0.0001) | <.001 |
| Female | −0.0258 (0.0055) | <.001 | −0.0031 (0.0041) | .46 |
| Race/ethnicity | - | .18 | - | .17 |
| Non-Hispanic white | Reference | - | Reference | - |
| Non-Hispanic black | −0.0085 (0.0059) | - | − 0.0009 (0.0044) | - |
| Mexican American | −0.0093 (0.0052) | - | −0.0066 (0.0036) | - |
| Other | 0.0067 (0.0175) | - | 0.0142 (0.0126) | - |
| Marital status | - | - | - | - |
| Never married | - | - | - | - |
| Divorced/separated | - | - | - | - |
| Widowed | - | - | - | - |
| Married/living with partner | - | - | - | - |
| Education (per additional year) | - | - | - | - |
| Income <$20,000 | 0.0148 (0.0055) | .008 | 0.0146 (0.0047) | .002 |
| Clinical risk factors and biomarkers | - | - | - | - |
| Ever smoker | 0.0120 (0.0046) | <.001 | 0.0071 (0.0043) | .10 |
| Diabetes | 0.0192 (0.0084) | .023 | 0.0321 (0.0094) | .001 |
| Hypertension | 0.0162 (0.0055) | .003 | 0.0119 (0.0040) | .003 |
| Relative with MI before age 50 | 0.0298 (0.0100) | .003 | - | - |
| Non-HDL-C (per SD increase) | 0.0083 (0.0022) | <.001 | 0.0035 (0.0018) | .06 |
| C-reactive protein (per 1 mg/dL) | 0.0065 (0.0015) | <.001 | 0.0034 (0.0013) | .01 |
| eGFR (mL/min/1.73 m2) | −0.0003 (0.0002) | .08 | - | - |
eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; Lp(a), lipoprotein(a); MI, myocardial infarction.