Supplement Table 4.

Association of Lp(a) with MI and stroke in multivariate analyses with polynomials and interactions included for the entire population and by sex or race/ethnicity at various dichotomous cut-points

Covariate	MI		Stroke
	OR (95% CI)	P-value	OR (95% CI)	P-value
Entire population	-	-	-	-
≥30 mg/dL	1.63 (1.09, 2.45)	.02	0.89 (0.58, 1.37)	.61
≥50 mg/dL	2.22 (1.36, 3.61)	.001	1.26 (0.77, 2.06)	.37
≥70 mg/dL	3.06 (1.51, 6.21)	.002	1.80 (0.88, 3.70)	.11
≥90 mg/dL	3.04 (1.20, 7.69)	.02	2.12 (0.83, 5.39)	.11
Male	-	-	-	-
≥30 mg/dL	1.75 (1.00, 3.09)	.052	0.84 (0.46, 1.54)	.57
≥50 mg/dL	2.96 (1.47, 5.95)	.002	1.01 (0.50, 2.06)	.98
≥70 mg/dL	4.27 (1.58, 11.53)	.004	1.18 (0.36, 3.85)	.78
≥90 mg/dL	4.03 (1.06, 15.3)	.04	1.03 (0.46, 2.30)	.95
Female	-	-	-	-
≥30 mg/dL	1.42 (0.87, 2.33)	.16	0.93 (0.49, 1.75)	.81
≥50 mg/dL	1.46 (0.84, 2.54)	.18	1.42 (0.70, 2.87)	.33
≥70 mg/dL	1.81 (0.80, 4.10)	.16	2.36 (0.93, 6.03)	.07
≥90 mg/dL	1.95 (0.63, 6.07)	.25	3.14 (0.89, 11.0)	.08
Non-Hispanic white	-	-	-	-
≥30 mg/dL	1.94 (1.22, 3.08)	.005	0.98 (0.57, 1.71)	.96
≥50 mg/dL	2.95 (1.68, 5.21)	<.001	1.34 (0.68, 2.66)	.39
≥70 mg/dL	4.99 (2.17, 11.49)	<.001	2.63 (0.99, 6.98)	.052
≥90 mg/dL	4.93 (1.60, 15.23)	.006	3.29 (0.93, 11.64)	.06
Non-Hispanic black	-	-	-	-
≥30 mg/dL	0.70 (0.41, 1.22)	.21	1.09 (0.57, 2.11)	.79
≥50 mg/dL	0.65 (0.37, 1.14)	.13	1.38 (0.76, 2.54)	.29
≥70 mg/dL	0.84 (0.44, 1.60)	.60	1.33 (0.65, 2.73)	.44
≥90 mg/dL	0.88 (0.34, 1.77)	.54	0.93 (0.42, 2.22)	.93
Mexican American	-	-	-	-
≥30 mg/dL	3.59 (1.65, 7.82)	.001	1.10 (0.42, 2.88)	.85
≥50 mg/dL	8.04 (3.52, 18.36)	<.001	1.36(0.31, 5.88)	.68
≥70 mg/dL	3.25 (0.63, 16.74)	.16	0.37 (0.05, 2.59)	.31
≥90 mg/dL	8.09 (0.77, 85.10)	.08	0.79 (0.11, 5.57)	.82

CI, confidence interval; Lp(a), lipoprotein (a); MI, myocardial infarction; OR, odds ratio