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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Am J Geriatr Psychiatry. 2020 May 5;29(1):51–62. doi: 10.1016/j.jagp.2020.04.026

FIGURE 1.

FIGURE 1.

Prefrontal cortical brain regions that mediate motivated behavior affected in Alzheimer’s disease. (A) Prefrontal cortical-basal ganglia circuits that play key roles in motivated behavior. Dashed lines represent indirect connections. (B) Tau pathology afflicts prefrontal cortical circuits, mediating motivated behaviors beginning in Braak Stage III/IV. dmPFC: dorsomedial prefrontal cortex; dlPFC: dorsolateral prefrontal cortex; oPFC: orbital prefrontal cortex; ACC: anterior cingulate cortex. Premotor: premotor cortex.