Figure 1.

Schematic representation of BRCA1 full-length and hypomorphic proteins that have been detected in cancers. (A) The full-length (p220) BRCA1 protein is depicted along with known functional domains and corresponding protein interactions. Amino acid (aa) residues corresponding to predicted domain start and end sites are indicated as well as potential functional activities of each domain. (B) BRCA1 cDNA is shown (above) with corresponding base pairs indicated. Redlines indicate regions where frameshift mutations may be present but remain capable of expressing either the BRCA1-ΔRING, BRCA1-Δ11q, or BRCA1-ΔBRCT proteins.