Table 5.
Comparison of genetic characteristics between eyes with versus without beta peripapillary atrophy at baseline
| Gene alleles* | Beta peripapillary atrophy | P-value | |
|---|---|---|---|
| No (n=155) | Yes (n=179) | ||
| CFH rs1061170 | 0.29 | ||
| CC | 47 (30.3%) | 48 (26.8%) | |
| TC | 78 (50.3%) | 88 (49.2%) | |
| TT | 30 (19.4%) | 43 (24.0%) | |
| ARMS2 rs1049092 | 0.0003 | ||
| GG | 37 (23.9%) | 61 (34.1%) | |
| GT | 68 (43.9%) | 93 (52.0%) | |
| TT | 50 (32.3%) | 25 (14.0%) | |
| HTRA1 rs1120063 | 0.001 | ||
| AA | 47 (30.3%) | 25 (14.0%) | |
| AG | 70 (45.2%) | 94 (52.5%) | |
| GG | 38 (24.5%) | 60 (33.5%) | |
| C3 rs2230199 | 0.41 | ||
| CC | 86 (55.5%) | 114 (63.7%) | |
| CG | 61 (39.4%) | 51 (28.5%) | |
| GG | 8 (5.2%) | 14 (7.8%) | |
| TLR3 rs3775291 | 0.31 | ||
| CC | 86 (55.5%) | 88 (49.2%) | |
| CT | 58 (37.4%) | 77 (43.0%) | |
| TT | 11 (7.1%) | 14 (7.8%) | |
*
The risk alleles are C for CFH, T for ARMS2, A for HTRA1, and G for C3. The protective allele is T for TLR3.