Table 2.
Eighteen new loci associated with BP traits that are at least 1Mb away from any known BP locus.
| Locus | Nearest Gene | rsID | Chr:Pos | EA | EAF (AFR/ASN/EUR/HIS) | Genetic Effect | GxE Interaction | P-value | Trait | Educ. | Anc. | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect | SE | Effect | SE | Interaction | 2DF Joint | |||||||||
| 1 | CDC14A | rs114558965 | 1:100829685 | a | 0.97/. /. /1.00 | −0.23 | 1.02 | 5.02 | 1.27 | 2.54E-03 | 2.86E-09 | SBP | SC | AFR |
| 2 | LIN01249 | rs9308788 | 2:4711095 | a | 0.02/0.22/0.06/0.06 | 2.97 | 2.13 | −11.93 | 2.64 | 5.04E-05 | 4.47E-08 | SBP | GC | AFR |
| 3 | ARL4C | rs145586115 | 2:235604646 | t | 0.97/. /. /0.99 | 4.80 | 0.87 | −2.57 | 1.29 | 1.16E-01 | 1.92E-08 | SBP | SC | AFR |
| 4 | CADPS | rs141962517 | 3:62514061 | t | 0.98/. /. /. | −2.46 | 1.54 | 12.85 | 2.23 | 1.99E-07 | 3.07E-10 | SBP | GC | AFR |
| 5 | PCDH7 | rs74458816 | 4:31363388 | a | 0.03/. /. /0.00 | −0.18 | 0.70 | −3.46 | 0.91 | 2.26E-03 | 4.90E-09 | MAP | SC | AFR |
| 6 | EIF4E | rs2141284 | 4:99704167 | a | . /. /0.01/0.01 | −1.35 | 0.22 | 1.01 | 0.38 | 2.16E-02 | 6.73E-09 | MAP | GC | TRANS |
| 7 | SPEF2 | rs115523707 | 5:35756623 | t | 0.03/. /0.00/0.00 | −0.83 | 0.64 | −2.73 | 0.88 | 5.91E-02 | 7.22E-09 | PP | SC | AFR |
| 8 | ANKRD34B | rs66907226 | 5:79863455 | d | 0.46/0.81/0.58/0.69 | 0.48 | 0.14 | 0.04 | 0.18 | 9.86E-01 | 4.43E-08 | SBP | SC | EUR |
| 9 | SLCO4C1 | rs114175587 | 5:100994204 | t | 0.02/. /. /0.00 | −4.84 | 0.83 | 3.84 | 1.29 | 3.55E-03 | 2.40E-08 | PP | SC | TRANS |
| 10 | SLIT3 | rs142385399 | 5:168166731 | a | 0.04/. /0.00/0.01 | 2.25 | 0.74 | −7.07 | 1.22 | 2.79E-08 | 4.76E-08 | DBP | GC | AFR |
| 11 | THSD7A | rs200612978 | 7:11493906 | d | 0.03/0.03/. /0.01 | −0.40 | 1.27 | −4.94 | 1.57 | 5.71E-02 | 4.81E-08 | SBP | SC | AFR |
| 12 | HAS2-AS1 | rs112332671 | 8:122673983 | a | 0.02/. /. /0.00 | −1.37 | 1.18 | −4.55 | 1.52 | 6.03E-02 | 1.89E-09 | PP | SC | AFR |
| 13 | CDON | rs12295584 | 11:125841078 | a | 0.95/. /0.99/0.99 | 2.87 | 0.57 | −1.07 | 0.84 | 2.20E-01 | 4.71E-08 | SBP | SC | TRANS |
| 14 | DSTNP2 | rs75535814 | 12:6996683 | t | 0.02/. /. /0.00 | −8.78 | 1.45 | 7.24 | 1.95 | 3.17E-04 | 5.79E-09 | SBP | SC | AFR |
| 15 | PIK3C2G | rs189555401 | 12:18443065 | t | 0.03/. /. /0.01 | −3.23 | 0.57 | 1.82 | 1.15 | 8.92E-02 | 4.10E-08 | DBP | GC | TRANS |
| 16 | E2F7; ZDHHC17 | rs17043233 | 12:77648216 | t | 0.02/. /. /0.00 | −4.07 | 0.58 | 4.26 | 0.90 | 1.72E-05 | 1.39E-11 | MAP | SC | TRANS |
| 17 | HRH4 | rs8099516 | 18:22108763 | t | 0.04/. /. /0.01 | 1.71 | 0.61 | −5.39 | 0.95 | 7.83E-09 | 5.04E-08 | DBP | GC | AFR |
| 18 | LOC100289473 | rs113809930 | 20:1711768 | a | 0.98/0.88/0.97/0.94 | −0.69 | 0.79 | 3.67 | 0.94 | 1.70E-03 | 3.48E-08 | DBP | SC | AFR |
Positions are based on build 37. Effect is in mmHg unit. BP: blood pressure; DBP: diastolic BP; EA: effect allele; EAF: effect allele frequency observed in our cohorts; MAP: mean arterial pressure; P: P-value of the joint test with 2 degrees of freedom of genetic main and interaction effects; PP: pulse pressure; SBP: systolic BP; SE: standard error; 2DF Joint 1DF Interaction P: P-value of the interaction test with 1 degree of freedom. The smallest P-values between 1DF interaction test and the joint 2DF test are in boldface
SC: SomeCol; GC: GradCol; EUR: European; AFR: African; TRANS; trans-ancestry (i.e., combining all ancestry groups through meta-analysis).