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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Physiol. 2020 May 30;598(15):3107–3127. doi: 10.1113/JP279612

Fig. 6.

Fig. 6.

A) Diameter recording of a popliteal lymphatic from a non-induced SMMHC-CreERT2;Kir6.1[GD-QR] mouse showing typical development of spontaneous contractions within a few minutes after equilibration at 37°C. B) In contrast, a popliteal lymphatic from a SMMHC-CreERT2;Kir6.1[GD-QR] mouse treated with TMX (2 weeks prior) does not develop spontaneous contractions even after 50 min. C) The vessel from the non-induced mouse shows a typical response to imposed pressure steps: an increase in contraction frequency and slight reduction in amplitude as pressure is elevated from 0.5 to 10 cmH2O. GLIB (10 μM GLIB) elevates basal frequency and slight reduces amplitude. D) The vessel from the induced mouse does not show contractions at any pressure, but develops weak, high-frequency contractions in the presence of GLIB.