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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Physiol. 2020 May 30;598(15):3107–3127. doi: 10.1113/JP279612

Table 2.

IC50 values determined from fits of pinacidil concentration-response relationships (using Hill equation) for popliteal lymphatics from WT, Kir6.1−/− and SUR2[STOP] mice.

Parameter WT Kir6.1−/− SUR2[STOP]
Normalized AMP IC50 (M) 3.4 ·10−7 1.4 ·10−4 7.0 ·10−4
Normalized FREQ IC50 (M) 1.3 ·10−7 8.3 ·10−5 4.1 ·10−4
Change in Tone IC50 (M) n/a n/a n/a

All parameters were normalized to those averaged over the 2-min period prior to administration of the first pinacidil dose. M = molar. n/a = could not be fit to Hill equation.