Table 1:
Clinical characteristics of patients with advanced NSCLC by SMARCA4 alteration class.
| Characteristic |
SMARCA4 Class 1 (N = 149) |
SMARCA4 Class 2 (N = 143) |
SMARCA4 Wild type (N = 996) |
P-value |
|---|---|---|---|---|
| Median Age (Q1, Q3) | 65 (58, 72) | 65 (59, 72) | 65 (58, 73) | 0.7 |
| Sex | 0.052 | |||
| Female | 74 (50%) | 78 (55%) | 593 (60%) | |
| Male | 75 (50%) | 65 (45%) | 403 (40%) | |
| Race | 0.13 | |||
| White | 124 (83%) | 125 (87%) | 775 (78%) | |
| Black | 7 (5%) | 7 (5%) | 57 (6%) | |
| Asian | 10 (7%) | 6 (4%) | 101 (10%) | |
| Other | 8 (5%) | 5 (4%) | 63 (6%) | |
| Smoking | <0.001 | |||
| Never smoker | 17 (11%) | 26 (18%) | 315 (32%) | |
| Former light (<15 py) | 20 (13%) | 19 (13%) | 165 (17%) | |
| Former heavy (>15 py) | 80 (54%) | 71 (50%) | 373 (37%) | |
| Current smoker | 32 (21%) | 27 (19%) | 131 (13%) | |
| Histology | <0.001 | |||
| Adenocarcinoma | 121 (81%) | 125 (87%) | 914 (92%) | |
| Other | 28 (19%) | 18 (13%) | 82 (8%) |
py: pack years