. 2019 Dec;7(12):1048–1058. doi: 10.1016/S2213-2600(19)30366-2

Table 2.

Bactericidal activity among patients with drug-susceptible tuberculosis over days 0–56 in the efficacy analysis population

	B_loadPaZ group (n=57)	B₂₀₀PaZ group (n=56)	HRZE group (n=59)
Daily percentage change in time to positive signal	4·87% (4·31–5·47)	5·17% (4·61–5·77)	4·04% (3·67–4·42)
Daily change in log(CFU) of overnight sputum samples	0·12 (0·11–0·14)	0·11 (0·10–0·12)	0·12 (0·11–0·13)

Data are posterior mean estimate (95% Bayesian credibility interval). The differences between the pairs of treatments B_loadPaZ versus HRZE and B₂₀₀PaZ versus HRZE were significant. B_loadPaZ=bedaquiline (loading dose), pretomanid, and pyrazinamide. B₂₀₀PaZ=bedaquiline (daily dose), pretomanid, and pyrazinamide. CFU=colony-forming unit. HRZE=isoniazid, rifampicin, pyrazinamide, and ethambutol.