Table 2.

Hazard ratios for overall mortality, colorectal cancer-specific mortality, and 5-year overall mortality among colorectal cancer patients by quartile of plasma vitamin D binding protein

	Hazard ratio (95% confidence interval)				Ptrend
	Quartile 1	Quartile 2	Quartile 3	Quartile 4
Mean (SD), μg/mL	125.2 (41.2)	213.5 (34.8)	274.6 (46.6)	383.5 (79.9)
No. of patients	149	151	152	151
Overall mortality
No. of events	81	84	76	70
Base modela	Referent	0.93 (0.68–1.26)	0.89 (0.65–1.21)	0.76 (0.55–1.04)	0.08
Multivariable modelb	Referent	0.77 (0.57–1.06)	0.69 (0.50–0.96)	0.58 (0.41–0.80)	0.001
Model further adjusted for total 25(OH)Dc	Referent	0.78 (0.57–1.06)	0.70 (0.50–0.96)	0.57 (0.41–0.79)	0.001
Colorectal cancer-specific mortality
No. of events	45	48	50	39
Base modela	Referent	1.02 (0.68–1.53)	1.08 (0.72–1.62)	0.80 (0.52–1.23)	0.39
Multivariable modelb	Referent	0.76 (0.50–1.15)	0.73 (0.48–1.11)	0.58 (0.37–0.91)	0.02
Model further adjusted for total 25(OH)Dc	Referent	0.75 (0.49–1.15)	0.73 (0.48–1.12)	0.56 (0.36–0.88)	0.02
5-year overall mortality
No. of events	53	54	51	39
Base modela	Referent	0.96 (0.66–1.40)	0.95 (0.65–1.40)	0.68 (0.45–1.02)	0.08
Multivariable modelb	Referent	0.74 (0.50–1.10)	0.68 (0.46–1.01)	0.50 (0.32–0.76)	0.001
Model further adjusted for total 25(OH)Dc	Referent	0.74 (0.50–1.09)	0.69 (0.46–1.02)	0.49 (0.32–0.75)	0.001

Abbreviations: 25(OH)D, 25-hydroxyvitamin D; SD, standard deviation.

^aAdjusted for age at diagnosis (continuous).

^bAddtionally adjusted for sex, body mass index (continuous), physical activity (continuous), cancer stage (I to IV or unknown), grade of tumor differentiation (well differentiated, moderately differentiated, poorly differentiated, unknown), location of primary tumor (proximal colon, distal colon, rectum, unknown), and year of diagnosis (continuous).

^cAdditionally adjusted for total 25-hydroxyvitamin D levels (quartiles).