Table 3.
Multivariable hazard ratios for overall mortality, colorectal cancer-specific mortality, and 5-year overall mortality among colorectal cancer patients by quartile of plasma vitamin D binding protein and time interval from blood collection to diagnosis
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Ptrend | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. of patients/events | HR (95% CI)a | No. of patients/events | HR (95% CI)a | No. of patients/events | HR (95% CI)a | No. of patients/events | HR (95% CI)a | ||
| Overall mortality | |||||||||
| ≥2 years | 149/81 | Referent | 151/84 | 0.77 (0.57–1.06) | 152/76 | 0.69 (0.50–0.96) | 151/70 | 0.58 (0.41–0.80) | 0.001 |
| ≥3 years | 138/72 | Referent | 141/80 | 0.83 (0.60–1.15) | 141/71 | 0.72 (0.51–1.01) | 140/61 | 0.61 (0.43–0.87) | 0.004 |
| ≥4 years | 130/66 | Referent | 131/74 | 0.84 (0.59–1.19) | 134/65 | 0.72 (0.51–1.03) | 131/58 | 0.63 (0.44–0.91) | 0.01 |
| ≥5 years | 124/60 | Referent | 125/71 | 0.87 (0.61–1.24) | 125/59 | 0.77 (0.53–1.11) | 125/56 | 0.68 (0.47–1.00) | 0.04 |
| Colorectal cancer-specific mortality | |||||||||
| ≥2 years | 149/45 | Referent | 151/48 | 0.76 (0.50–1.15) | 152/50 | 0.73 (0.48–1.11) | 151/39 | 0.58 (0.37–0.91) | 0.02 |
| ≥3 years | 138/40 | Referent | 141/45 | 0.76 (0.49–1.19) | 141/46 | 0.73 (0.46–1.13) | 140/33 | 0.60 (0.37–0.96) | 0.04 |
| ≥4 years | 130/35 | Referent | 131/42 | 0.77 (0.48–1.24) | 134/41 | 0.74 (0.46–1.19) | 131/30 | 0.58 (0.35–0.97) | 0.05 |
| ≥5 years | 124/35 | Referent | 125/38 | 0.70 (0.43–1.14) | 125/37 | 0.76 (0.47–1.23) | 125/29 | 0.58 (0.35–0.98) | 0.07 |
| 5-year overall mortality | |||||||||
| ≥2 years | 149/53 | Referent | 151/54 | 0.74 (0.50–1.10) | 152/51 | 0.68 (0.46–1.01) | 151/39 | 0.50 (0.32–0.76) | 0.001 |
| ≥3 years | 138/46 | Referent | 141/51 | 0.79 (0.52–1.20) | 141/47 | 0.71 (0.47–1.08) | 140/35 | 0.54 (0.34–0.85) | 0.007 |
| ≥4 years | 130/42 | Referent | 131/48 | 0.78 (0.50–1.20) | 134/43 | 0.71 (0.46–1.10) | 131/32 | 0.50 (0.31–0.80) | 0.005 |
| ≥5 years | 124/42 | Referent | 125/45 | 0.72 (0.46–1.13) | 125/39 | 0.71 (0.46–1.12) | 125/30 | 0.47 (0.29–0.77) | 0.004 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
a
Adjusted for age at diagnosis (continuous), sex, body mass index (continuous), physical activity (continuous), cancer stage (I to IV or unknown), grade of tumor differentiation (well differentiated, moderately differentiated, poorly differentiated, unknown), location of primary tumor (proximal colon, distal colon, rectum, unknown), and year of diagnosis (continuous).