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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Trends Biochem Sci. 2020 Sep 4;45(12):1065–1079. doi: 10.1016/j.tibs.2020.08.001

Table 1.

List of cargo molecules in GRASPs-dependent unconventional protein secretion.

Name Species GRASP binding Cargo type Reference
AcbA Dictyostelium Not reported cytosolic [78]
Acb1 Yeast Not reported cytosolic [79, 80]
SOD1 Yeast Not reported cytosolic [105]
Udp2 Drosophila Not reported cytosolic [81]
IL-1β Human Not reported cytosolic [82, 106]
IL-18 Human Not reported cytosolic [82, 83]
HMGB1 Human Not reported cytosolic [83]
IDE Human Not reported cytosolic [84]
TGFB1 Human Yes cytosolic [87]
αPS1 integrin Drosophila Not reported transmembrane [90]
αPS2 integrin Drosophila Not reported transmembrane [90, 107]
CLRN1N48K Zebrafish Not reported transmembrane [96]
ΔF508-CFTR Human Yes transmembrane [91]
Mpl Human Not reported transmembrane [94]
TACE Human Not reported transmembrane [95]

Abbreviations: AcbA, acyl coenzyme A (CoA) binding protein; SOD1, superoxide dismutase 1; IL-1β, Interleukin-1β; IL-18, Interleukin-18; HMGB1, high mobility group box 1; IDE, insulin-degrading enzyme; TGFB1, transforming growth factor beta 1; CLRN1, Clarin-1; CFTR, cystic fibrosis transmembrane conductance regulator; Mpl, myeloproliferative leukemia virus oncogene; TACE, tumor necrosis factor-α converting enzyme.