Table 3.

High-risk characteristics of patients by pathogenic variant status and gene

	Pathogenic variant in:
	ATM	BRCA1	BRCA2	CDH1	RAD50	Any pathogenic variant	No pathogenic variant	p-value*
TN	1 (17%)	2 (33%)	0 (0%)	0 (0%)	0 (0%)	3 (12%)	31 (20%)
Not TN	5 (83%)	4 (67%)	8 (100%)	1 (100%)	3 (100%)	21 (88%)	127 (80%)	0.58
Age <50	1 (17%)	2 (33%)	2 (25%)	1 (100%)	1 (33%)	7 (29%)	55 (34%)
Age 50+	5 (83%)	4 (67%)	6 (75%)	0 (0%)	2 (67%)	17 (71%)	98 (64%)	0.65
FH breast cancer	2 (33%)	2 (33%)	2 (25%)	1 (100%)	1 (33%)	9 (37%)	43 (27%)	0.33
No FH breast cancer	4 (67%)	4 (67%)	6 (75%)	0 (0%)	2 (67%)	15 (63%)	115 (73%)
Suggestive FH	1 (17%)	1 (17%)	2 (25%)	0 (0%)	1 (33%)	5 (21%)	29 (18%)
No suggestive FH	5 (83%)	5 (83%)	6 (75%)	1 (100%)	2 (67%)	19 (79%)	129 (82%)	0.78

^*Fisher’s exact test comparing any pathogenic variant carriers to non-carriers