Shown are statistical parametric maps showing significant difference in
brain activation in sedated WAS rats compared to controls during bladder filling
with and without prior exposure to ceftriaxone (CTX). Changes in regional
cerebral blood flow related tissue radioactivity are depicted on representative
coronal sections (anterior–posterior coordinates relative to the bregma)
of the template brain. Color-coded overlays show statistically significant group
differences, with red and blue colors showing positive and negative changes,
respectively (P<0.05 at the voxel level for clusters of >100
contiguous voxels). Abbreviations are based on the rat brain atlas 74 with modifications.
Acb n. acumbens AH anterior hypothalamus Au auditory cx BL basolateral
amygdala BLA basolateral amygdala BM basomedial amygdala Cg1 dorsal anterior
cingulate cx pCg/antRS post. cingulate/ ant. retrosplenial cx CPu striatum dmCPu
dorsomedial striatum HPC hippocampus I insula LA lateral amygdala LCC locus
coeruleus complex LD lateral dorsal thalamic n. LO lateral orbital cx LSI
lateral septum M1 primary motor cx M2 secondary motor cx MD mediodorsal thalamic
n. MeA medial amygdala MG medial geniculate pCg posterior cingulate cx PAG
periaqueductal gray, PBN parabrachial n. PMCo cortical amygdala Pir piriform
cortex PrL prelimbic cx PtA parietal association cx RS retrosplenial cx S1BF
primary somatosens. cx barrel field area S1FL primary somatosens. cx forelimb
area S1J primary somatosens. cx jaw area S1Tr primary somatosens. cx trunk area
S1ULp primary somatosens. cx upper lip area S2 secondary somatosens. cx Sim
simple cerebellar lobule SO superior olive STN subthalamic n. V1 primary visual
cx V2 secondary visual cx vCPu ventral striatum VL ventrolateral thalamic n. VMH
ventromedial hypothalamus VO ventral orbital cx VPL ventral post. lateral
thalamic n. VPL/VPM ventral post. lateral/ventral post. medial thalamic n. VPM
ventral posterior medial thalamic n. ZI zona incerta