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Terminal duct lobular unit (TDLU) involution was evaluated among 827 controls using qualitative categories—no type 1 lobules (n=114), mixed lobule types (n=409), and predominant type 1 and no type 3 lobules (n=334). TDLU involution was significantly correlated with age at BBD biopsy (p-trend <0.001; A) and significantly inversely correlated with the eight quantitative measures derived from our automated method (p-trend <0.001; B-I).
