Fig. 3.

CUDC-907 induces DNA damage response in breast cancer cells. a CUDC-907 treatment increased γ-H2AX foci formation. Cells were treated with CUDC-907 for 24 h, and then fixed 20 min for immunofluorescence analysis of γ-H2AX foci. Nuclei were visualized by DAPI. b Representative Western blotting results showing γ-H2AX expression after incubation with CUDC-907 for 24 h in breast cancer cells. β-Actin was used as a loading control